Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Isotype |
IgG |
Applikationen |
WB |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ111939-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q92819 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 67-185 of human HAS2 (NP_005319. 1). |
Short Description |
Rabbit polyclonal against HAS2 |
Tissue specificity |
Expressed in fibroblasts. |
Cellular localization |
MembraneMulti-Pass Membrane Protein |
Molecular weight |
Calculated: 63kDa. Observed: 70kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Hyaluronan Synthase 2 antibodyAnti-Hyaluronate Synthase 2 antibodyAnti-Hyaluronic Acid Synthase 2 antibodyAnti-Ha Synthase 2 antibodyAnti-HAS2 antibody |
Protein name |
Hyaluronan Synthase 2Hyaluronate Synthase 2Hyaluronic Acid Synthase 2Ha Synthase 2 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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