Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Isotype |
IgG |
Applikationen |
WB |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
STJ117024-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9Y287 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 81-266 of human ITM2B (NP_068839. 1). |
Short Description |
Rabbit polyclonal against ITM2B |
Tissue specificity |
Ubiquitous. Expressed in brain. |
Cellular localization |
Integral Membrane Protein 2b: Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinImmature Bri2 (Imbri2) Is Cleaved By Furin In The Golgi Into Mbri2 And A Bri23 PeptideMbri2 Is Transported To The Plasma Membrane And Bri23 Peptide Is SecretedBri2Membrane Form: Cell MembraneEndosome MembraneMature Bri2 (Mbri2) Needs To Be Transported From The Endoplasmic Reticulum Compartment To The Cell Membrane In Order To Be Able To Inhibit App ProcessingBri23 Peptide: SecretedDetected In The Cerebral Spinal Fluid (Csf)Bri2cSoluble Form: Secreted |
Molecular weight |
Calculated: 18kDa/30kDa. Observed: 30kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Integral Membrane Protein 2b antibodyAnti-Immature Bri2 antibodyAnti-Imbri2 antibodyAnti-Protein E25b antibodyAnti-Transmembrane Protein Bri antibodyAnti-Bri Cleaved Into-Bri2-Membrane Form antibodyAnti-Mature Bri2 antibodyAnti-Mbri2-Bri2 Intracellular Domain antibodyAnti-Bri2 Icd-Bri2c-Soluble Form-Bri23 Peptide antibodyAnti-Bri2-23 antibodyAnti-Abri23 antibodyAnti-C-Terminal Peptide antibodyAnti-P23 Peptide antibodyAnti-ITM2B BRI BRI2 antibody |
Protein name |
Integral Membrane Protein 2bImmature Bri2Imbri2Protein E25bTransmembrane Protein BriBri Cleaved Into-Bri2-Membrane FormMature Bri2Mbri2-Bri2 Intracellular DomainBri2 Icd-Bri2c-Soluble Form-Bri23 PeptideBri2-23Abri23C-Terminal PeptideP23 Peptide |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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