ArtNr |
STJ114198-50 |
Hersteller |
St John's Laboratory
|
Menge |
50 ul |
Quantity options |
100 ul
200 ul
50 ul
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human (Homo sapiens) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Unconjugated |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Tumor Necrosis Factor Ligand Superfamily Member 10 antibody, Anti-Apo-2 Ligand antibody, Anti-Apo-2l antibody, Anti-Tnf-Related Apoptosis-Inducing Ligand antibody, Anti-Protein Trail antibody, Anti-Cd Antigen Cd253 antibody, Anti-TNFSF10 APO2L TRAIL antibody |
Similar products |
Anti-Tumor Necrosis Factor Ligand Superfamily Member 10 antibodyAnti-Apo-2 Ligand antibodyAnti-Apo-2l antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand antibodyAnti-Protein Trail antibodyAnti-Cd Antigen Cd253 antibodyAnti-TN |
Lieferbar |
|
Storage Conditions |
Store at-20°C and avoid freeze-thaw cycles. |
Molecular Weight |
Calculated: 11kDa/32kDa. |
Description |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFSF10 (NP_003801. 1). |
Tissue specificity |
Widespread.most predominant in spleen, lung and prostate. |
Cellular localization |
Cell Membrane Single-Pass Type Ii Membrane Protein Secreted Exists Both As Membrane-Bound And Soluble Form |
Clonality |
Polyclonal |
Protein name |
Tumor Necrosis Factor Ligand Superfamily Member 10 Apo-2 Ligand Apo-2l Tnf-Related Apoptosis-Inducing Ligand Protein Trail Cd Antigen Cd253 |
Gene symbol |
TNFSF10 |
Dilution range |
WB 1:500-1:2000 |
Note |
For Research Use Only (RUO). |
Short Description |
Rabbit polyclonal against TNFSF10 |
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