|
Hersteller |
St John's Laboratory
|
|
Kategorie |
|
|
Typ |
Antibody Polyclonal |
|
Specific against |
Human |
|
Isotype |
IgG |
|
Applikationen |
WB |
|
Menge |
50ul |
|
Host |
Rabbit |
|
ArtNr |
STJ114198-50 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Clonality |
Polyclonal |
| Conjugation |
Unconjugated |
| Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification |
Affinity purification |
| Uniprot ID |
P50591 |
| Storage |
Store at-20° C and avoid freeze-thaw cycles. |
| Description |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Gene ID |
|
| Gene symbol |
|
| Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFSF10 (NP_003801. 1). |
| Short Description |
Rabbit polyclonal against TNFSF10 |
| Tissue specificity |
Widespread.most predominant in spleen, lung and prostate. |
| Cellular localization |
Cell MembraneSingle-Pass Type Ii Membrane ProteinSecretedExists Both As Membrane-Bound And Soluble Form |
| Molecular weight |
Calculated: 11kDa/32kDa. |
| Dilution range |
WB 1:500-1:2000 |
| Alternative names |
Anti-Tumor Necrosis Factor Ligand Superfamily Member 10 antibodyAnti-Apo-2 Ligand antibodyAnti-Apo-2l antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand antibodyAnti-Protein Trail antibodyAnti-Cd Antigen Cd253 antibodyAnti-TNFSF10 APO2L TRAIL antibody |
| Protein name |
Tumor Necrosis Factor Ligand Superfamily Member 10Apo-2 LigandApo-2lTnf-Related Apoptosis-Inducing LigandProtein TrailCd Antigen Cd253 |
| Note |
FOR RESEARCH USE ONLY (RUO). |
| Swiss port key |
|
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