Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human |
Isotype |
IgG |
Applikationen |
IF |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ114199-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9Y4L1 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human HYOU1 (NP_001124463. 1). |
Short Description |
Rabbit polyclonal against HYOU1 |
Tissue specificity |
Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. |
Cellular localization |
Endoplasmic Reticulum Lumen |
Molecular weight |
Calculated: 62kDa/111kDa. Observed: |
Dilution range |
IF 1:50-1:200 |
Alternative names |
Anti-Hypoxia Up-Regulated Protein 1 antibodyAnti-150 Kda Oxygen-Regulated Protein antibodyAnti-Orp-150 antibodyAnti-170 Kda Glucose-Regulated Protein antibodyAnti-Grp-170 antibodyAnti-HYOU1 GRP170 ORP150 antibody |
Protein name |
Hypoxia Up-Regulated Protein 1150 Kda Oxygen-Regulated ProteinOrp-150170 Kda Glucose-Regulated ProteinGrp-170 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
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