Antibodies

Anti-HYOU1 Antibody

Hersteller St John's Laboratory
Kategorie
Typ Antibody
Specific against Human
Applikationen IF
Menge 50ul
Host Rabbit
ArtNr STJ114199-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Description
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.
Short Description
Rabbit polyclonal to HYOU1
Alternative names
HYOU1 antibody
Hypoxia up-regulated protein 1 antibody
150 kDa oxygen-regulated protein antibody
ORP-150 antibody
170 kDa glucose-regulated protein antibody
GRP-170 antibody
HYOU1 antibody
GRP170 antibody
ORP150 antibody
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution range
IF 1:50 - 1:200
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene id
Gene symbol
Immunogen
Recombinant protein of human HYOU1
Iso type
IgG
Molecular weight
111.335 kDa
Note
For Research Use Only (RUO).
Purification
Affinity purification
Storage instruction
Store at -20C. Avoid freeze / thaw cycles.
Swiss prot key
Tissue specificity
Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins, Highly expressed in liver and pancreas and lower expression in brain and kidney, Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers
Uniprot id
Q9Y4L1

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Menge: 50ul
Lieferbar: In stock
Listenpreis: 235,71 €
Preis: 235,71 €
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