Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human |
Isotype |
IgG |
Applikationen |
IF |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ114276-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P25445 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant protein of human FAS |
Short Description |
Rabbit polyclonal against FAS |
Tissue specificity |
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. |
Cellular localization |
Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: SecretedIsoform 4: SecretedIsoform 5: SecretedIsoform 6: Secreted |
Molecular weight |
Calculated: 9kDa/11kDa/14kDa/16kDa/24kDa/35kDa/37kDa. Observed: |
Dilution range |
IF 1:50-1:100 |
Alternative names |
Anti-Tumor Necrosis Factor Receptor Superfamily Member 6 antibodyAnti-Apo-1 Antigen antibodyAnti-Apoptosis-Mediating Surface Antigen Fas antibodyAnti-Faslg Receptor antibodyAnti-Cd Antigen Cd95 antibodyAnti-FAS APT1 FAS1 TNFRSF6 antibody |
Protein name |
Tumor Necrosis Factor Receptor Superfamily Member 6Apo-1 AntigenApoptosis-Mediating Surface Antigen FasFaslg ReceptorCd Antigen Cd95 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.