Anti-FAS Antibody

Hersteller St John's Laboratory
Kategorie
Typ Antibody
Specific against Human
Applikationen IF
Menge 50ul
Host Rabbit
ArtNr STJ114276-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Short Description
Rabbit polyclonal to FAS
Alternative names
FAS antibody
Tumor necrosis factor receptor superfamily member 6 antibody
Apo-1 antigen antibody
Apoptosis-mediating surface antigen FAS antibody
FASLG receptor antibody
CD antigen CD95 antibody
FAS antibody
APT1 antibody
FAS1 antibody
TNFRSF6 antibody
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution range
IF 1:50 - 1:100
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene id
Gene symbol
Immunogen
Recombinant protein of human FAS
Iso type
IgG
Molecular weight
37.732 kDa
Note
For Research Use Only (RUO).
Purification
Affinity purification
Storage instruction
Store at -20C. Avoid freeze / thaw cycles.
Swiss prot key
Tissue specificity
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells, After activation there is an increase in isoform 1 and decrease in the levels of isoform 6
Uniprot id
P25445

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Menge: 50ul
Lieferbar: In stock
Listenpreis: 235,71 €
Preis: 235,71 €
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