Anti-Tubulin beta III antibody (KLH)

Store at-20°C, and avoid repeated freeze-thaw cycles.

Tubulin was the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin was found almost exclusively in neuronal processes of adult tissues and was therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and was correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)

This antibody was protein g purified culture from supernatant.

Cytoplasm
Cytoskeleton
Cell Projection
Lamellipodium
Filopodium

Tubulin Beta-3 Chain
Neuron-Specific Class Iii Beta-Tubulin

For Research Use Only (RUO).