Recombinant Human IL-10 (Carrier-free)

IL-10 is elaborated and secreted by macrophages, monocytes, T cells, B cells and keratinocytes and is well characterized as a potent immunosuppressive and anti-inflammatory cytokine. IL-10 has been shown to exert inhibitory effects on Th0, Th1 and Th2 subsets and monocytes. IL-10 has been shown also to inhibit expression of co-stimulatory molecules such as CD80 and CD86 on antigen presenting cells. IL-10 has also been shown to enhance B-cell and other responses in specific scenarios. Because of its pleiotropic role, IL-10 has been explored as a therapeutic agent in inflammatory diseases and cancer.

MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N

The ED₅₀ was found to be 2.0 ng/ml, corresponding to a specific activity of 5 x 10^5 units/mg determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells.

This recombinant protein is 161 amino acid residues with a molecular weight of 18.6 kDa.

AIDS/HIV; Cancer; Immune System; Inflammation; Neurobiology; Stem Cells & Differentiation; Allergy; Transplantation

See Certificate of Analysis (COA) for lot specific reconstitution information.