BCL10,NT (BCL10,CIPER,CLAP,B Cell lymphoma/leukemia 10,B Cell CLL/lymphoma 10,CARD-containing molecule enhancing NF-kappa-B,CARD-like apoptotic protein,CED-3/ICH-1 prodomain homologous E10-like regulator,Cellular homolog

Antibodies / Antibodies-Cancer Markers, Leukemia

4°C Do Not Freeze

Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 24-51 in the N-terminal region of human BCL10, UniProt Accession #O95999.
Species Sequence Homology: rat

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry (Not Tested) and FLISA. Other applications have not been tested.

Recommended Dilutions:
Immunohistochemistry: Formlin-fixed, paraffin-embedded sections
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.