DDR2 (DDR2,NTRKR3,TKT,TYRO10,Discoidin domain-containing receptor 2,CD167 antigen-like family member B,Discoidin domain-containing receptor tyrosine kinase 2,Neurotrophic tyrosine kinase,receptor-related 3,Receptor prote

Antibodies / Antibodies-Receptors, Tyrosine Kinase

-20°C

Supplied as a liquid, 0.09% sodium azide.

Purified His-tagged DDR2 protein (fragment).

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq].

Applications:
Suitable for use in Western Blot, ELISA.

Recommended Dilution:
ELISA: 1:1, 000
Western Blot: 1:100~1600

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.