ALK, CT (Anaplastic lymphoma kinase, CD246 antigen)

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1591ca.1620 amino acids from the C-terminal region of human ALK.

ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2; 5)(p23; q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.

Applications:
Suitable for use in Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1, 000
Immunohistochemistry: 1:50-100

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.