BLNK,NT (BLNK,BASH,SLP65,B Cell linker protein,B Cell adapter containing a SH2 domain protein,B Cell adapter containing a Src homology 2 domain protein,Cytoplasmic adapter protein,Src homology 2 domain-containing leukocy

Antibodies / Antibodies-Adapter Proteins

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-82 amino acids from the N-terminal region of human BLNK.

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1, 000
Western Blot: 1:50-100

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.