Connexin 30.3, CT (Gap junction beta-4 protein, Connexin-30.3, Cx30.3, GJB4,)

Antibodies / Antibodies-Connexin, Junction Proteins

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Connexin 30.3 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237ca.266 amino acids from the C-terminal region of human GJB4.

Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. Erythrokeratodermia variabilis (EKV) is an autosomal dominant disorder of keratinization characterized by migratory erythematous lesions and fixed keratotic plaques. Mutations in the GJB3 gene have been reported in some but not all families, although it has been postulated that the absence of connexin 30.3 can be compensated by other connexins.

Applications:
Suitable for use in Western Blot, ELISA

Recommended Dilution:
ELISA: 1:1, 000
Western Blot: 1:50-100

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.