SILV,ID (PMEL,D12S53E,PMEL17,SILV,Melanocyte protein PMEL,ME20-M,Melanocyte protein Pmel 17,Melanocytes lineage-specific antigen GP100,Melanoma-associated ME20 antigen,P1,P100,Premelanosome protein,Silver locus protein h

Antibodies / Antibodies-Cancer Markers

-20°C

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 412-440 in the central region of human SILV, UniProt Accession #P40967.

SILV plays a central role in the biogenesis of melanosomes. It is involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

Applications:
Suitable for use in FLISA and Western Blot. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Note: Applications are based on unconjugated antibody.