PSAP (Cerebroside Sulfate Activator, FLJ00245, GLBA, MGC110993, Prosaposin, SAP1)

Antibodies / Antibodies-Enzymes, Phosphatase

-20°C

Supplied as a liquid in PBS, pH 7.2.

Full length human PSAP, aa1-524 (NP_002769.1).

Prosaposin is a highly conserved 66kD glycoprotein which contains separate domains in tandem for four saposins, A, B, C, and D. These saposins are involved in lysosomal hydrolysis of GM1 ganglioside, gluco- and galactocerebrosides, sulfatides, and sphingomyelin and other sphingolipids. It also exists as a secretory protein in body fluids. Deficiency of PSAP saposin-B, PSAP saposin-C and PSAP saposin-D region are the cause of a variant of metachromatic leukodystrophy, atypical Gaucher disease and Tay-Sachs disease respectively. Alternative splicing results in multiple transcript variants encoding different isoforms. The gene maps to 10q21-q22 region of human chromosome.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

AA Sequence:
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.