Cofactor Required for Sp1 Transcriptional Activation Subunit 2, 150kD (CRSP2, CRSP150, CXorf4, DRIP150, MGC104513, RGR1, TRAP170)

Antibodies / Antibodies-Transcription Factors

-20°C

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

Partial sequence of recombinant full-length human CRSP2 protein (PASFVPTPPP SSHGISIGPG ASFASPHGTL DPSSPYTMVS PSGRAGNWPG SPQVSGPSPA ARMPGMSPAN PSLHSPVPDA SHSPRAGTSS QTMPTNMPPP RKLPQRSW)

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This protein is known to escape chromosome X-inactivation.

Applications:
Suitable for use in Western Blot and Dot Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.