mTOR,NT (Mammalian Target of Rapamycin,Mechanistic Target of Rapamycin (Serine/threonine Kinase),FK506-binding Protein 12-rapamycin Complex-associated Protein 1,FKBP12-rapamycin Complex-associated Protein,FRAP,FRAP1,FRAP

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid in PBS, 0.02% sodium azide.

Synthetic peptide corresponding to 15aa from human TOR at N-terminal (KLH).

mTOR, a T-cell binding protein is involved in the rapamycin pathway thus leading to progression of G1 phase of cell cycle and are known to mediate cellular responses to stresses like DNA damage and nutrient deprivation. It belongs to a family of phosphatidylinositol kinase-related kinases and possesses a PI3K catalytic domain and a FAT domain. It acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. It is ubiquitously expressed in most of the tissues and is involved in suppression of Kv1.1 channel mRNA translation in dendrites. It controls the expression of ribosomal protein genes via FHL1.

Applications:
Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.