PIK3CG,phosphorylated (Ser1100) (Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit gamma Isoform,PtdIns-3-kinase Subunit gamma,PI3K-gamma,Phosphatidylinositol-4,5-bisphosphate 3-kinase 110kD Catalytic Subu

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid in PBS, 0.09% sodium azide.

Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser1100 of human PIK3CG (KLH).

PIK3CG belongs to the pi3/pi4-kinase family of proteins. It is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene for this protein is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

Applications:
Suitable for use in ELISA and Dot Blot. Other applications not tested.

Recommended Dilutions:
ELISA: 1:1000
Dot Blot: 1:500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.