Sex Hormone-Binding Globulin (SHBG, Sex Steroid-binding Protein, SBP, Testis-specific Androgen-binding Protein, BP, Testosterone-estradiol-binding Globulin, TeBG, Testosterone-estrogen-binding Globulin)

Antibodies / Antibodies-Hormones, Steroids

-20°C

Supplied as a liquid in PBS, 0.09% sodium azide

Purified human SHBG protein.

SHBG is a protein of mol wt 90kD (402aa) containing two subunits. SHBG transports the sex steroids testosterone, DHT and estradiol in the blood. Serum levels are increased during pregnancy, in women taking estrogens, and in men over the age of 50. Levels are reduced after menopause and in response to treatment with androgens or corticosteroids. Diagnostic uses include polycystic ovary disease and tests for liver and thyroid function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilutions:
ELISA: 1:10, 000-1:100, 000
Western Blot: 1:1000-1:5000 using Chemiluminescence
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.