VAMP 2 (Vesicle Associated Membrane Protein 2, Vesicle-associated Membrane Protein 2, VAMP2, VAMP-2, FLJ11460, Synaptobrevin 2, Synaptobrevin-2, SYB 2, SYB2, SYB-2)

Antibodies / Antibodies-Membrane Proteins

-20°C

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

Synthetic peptide corresponding to aa1-50 of rat VAMP-2.

VAMP-2 is a member of the vesicle-associated membrane protein (VAMP):synaptobrevin family, which are 18kD integral membrane proteins originally characterized in synaptic vesicles. The protein forms a stable complex with syntaxin, synaptosomal-associated protein and synaptotagmin which are main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP-2 plays a key role in the fusion of synaptic vesicles. VAMP-2 is also expressed in non-neuronal tissue and participates in regulated exocytosis, such as insulin-regulated translocation of glucose transporter-4 (GLUT4)-containing vesicles in adipocytes and insulin secretion in pancreatic beta-cells. In human, the pathological role of the protein has been identified in familial infantile myasthenia (FIMG). The rat VAMP-2 gene is localized on chromosome 10q24.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Brain

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.