CD51 (CD51 Antigen, Integrin alpha V, ITGAV, Msk8, Vitronectin Receptor alpha Polypeptide, Vitronectin Receptor Subunit alpha, VNRA)

Antibodies / Antibodies-CD Markers

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

BALB/c mouse IL-2-activated killer (LAK) cells

CD51 is a 140kD protein, also known as aV integrin, vitronectin receptor, and integrin aV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins b1, b3, b5 or b6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The av integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. This antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Applications:
Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested.

Recommended Dilution:
Flow Cytometry: ≤1ug/10e6 cells in 100ul volume
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.