Clostridium botulinum Toxin A (BoNT/A, Bontoxilysin-A)

Antibodies / Antibodies-Infectious Disease Clostridium

-20°C

Supplied as a liquid in PBS, pH 7.2, 20% glycerol. No preservatives added.

Type A Neurotoxin Light Chain

Clostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln--Arg-198 bond of SNAP-25.

Applications:
Suitable for use in ELISA, Dot Blot and Western Blot. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.