FGFR4, Recombinant, Human, aa22-369, His-Tag (Fibroblast Growth Factor Receptor 4 Isoform 1)

Molecular Biology / MB-Receptors

-20°C

Highly Purified

FGFR4, as known as fibroblast growth factor receptor 4 isoform 1, is a glycosylated transmembrane receptor tyrosine kinase. This protein is widely expressed during embryonic development and in adult liver, kidney, and lung. Also, it is associates with beta-Klotho and sulfated glycosaminoglycans, and these interactions increase the affinity of FGFR4 for its ligands as well as its signaling capacity. This receptor signaling is additionally required for skeletal muscle development in limbs.

Source:
Recombinant protein corresponding to aa22-369 from human FGFR4, fused to His-Tag at C-terminal, expressed in insect cell.

Molecular Weight:
~39.5kD (356aa) 40-57kD (SDS-PAGE under reducing conditions)

Endotoxin:
~1EU/1ug (LAL)

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.