PIM1 Rabbit pAb

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

A synthetic peptide corresponding to a sequence within amino acids 213-313 of human PIM1 (NP_002639.1).

Epigenetics & Nuclear Signaling, Chromatin Modifying Enzymes, Phosphorylation, Chromatin Remodeling, Cancer, Signal Transduction, Kinase, Serine/threonine kinases, Cell Biology & Developmental Biology, Apoptosis, Immunology & Inflammation, IL-6 Receptor Signaling Pathway, Stem Cells, Hematopoietic Progenitors.

35kDa/45kDa