Twist Rabbit pAb

Polyclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.

This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of Twist (NP_000465.1).

21kDa

Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Cell Biology Developmental Biology, Neuroscience, Cell Type Marker, Stem Cells, Cardiovascular, Heart, Cardiogenesis, Neuron marker.

7291

TWIST1