Calsyntenin 1 (CLSTN1) Antibody

Primary Antibodies

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).

PBS containing 0.09% sodium azide.

CLSTN1

Purified through a protein A column, followed by peptide affinity purification.

Predicted to react with Mouse and Rat CLSTN1.