Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Antibody

Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).

PBS containing 0.09% sodium azide.

This product is for research use only.

IF2A_HUMAN