RRM1 Antibody

RRM1 Antibody is a Rabbit Polyclonal antibody against RRM1. Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B(PMID:16376858). RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells(PMID:8188248). Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival(PMID:17314339). This antibody is specific to RRM1.

Image Legend: Fig. 1. Western blot analysis of extracts of HeLa cells tissue, using RRM1 antibody.

Unconjugated

Affinity purified.

P23921

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This product is for research use only.