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RRM1 Antibody

RRM1 Antibody

Manufacturer	Abbexa
Type	Antibody Primary
Specific against	Human, Mouse, Rat, Monkey
Isotype	IgG
Applications	WB, FC, IF, IP, IHC, ICC
Amount	50 ul
Host	Rabbit
Item no.	abx000777-50
eClass 6.1	32160702
eClass 9.0	32160702
Available
Origin	Human
Description	RRM1 Antibody is a Rabbit Polyclonal antibody against RRM1. Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B(PMID:16376858). RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells(PMID:8188248). Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival(PMID:17314339). This antibody is specific to RRM1. Image Legend: Fig. 1. Western blot analysis of extracts of HeLa cells tissue, using RRM1 antibody.
Antigen	RRM1
Conjugation	Unconjugated
Immunogen	Recombinant protein of human RRM1.
Purification	Affinity purified.
Storage	Aliquot and store at -20 C. Avoid repeated freeze/thaw cycles.
Swiss Prot	P23921
Molecular Weight	90 kDa
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Lead Time	Shipped within 5-10 working days.
Note	This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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