Myelin Basic Protein (MBP) Antibody

Myelin Basic Protein (MBP)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

The classic group of MBP isoforms (isoforms 4-14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoforms 1-3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.

Ascitic fluid containing 0.03% sodium azide.

MBP

Unpurified ascites.

159430