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Protein-Tyrosine Phosphatase H1 (PTPH1) Antibody Europäischer Partner

ArtNr abx033945-400
Hersteller Abbexa
Menge 400 ul
Quantity options 400 ul 80 ul
Kategorie
Typ Antibody Primary
Format Liquid
Applikationen WB, IHC, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products PTPH1
Lieferbar
Manufacturer - Category
Primary Antibodies
Manufacturer - Targets
Protein-Tyrosine Phosphatase H1 (PTPH1)
Manufacturer - Conjugate / Tag
Unconjugated
Storage Conditions
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight
Calculated MW: 104 kDa
Description
Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
Dry Ice
No
Buffer
PBS containing 0.09% sodium azide.
Clonality
Polyclonal
Note
This product is for research use only.
Purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
UniProt Entry Name
PTN3_HUMAN

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 400 ul
Lieferbar: In stock
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Lieferung vsl. bis 31.07.2025 

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