PMS2/PMS2CL Polyclonal Antibody

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The protein encoded by PMS2 (PMS1 homolog 2, mismatch repair system component) is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X)2E (X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in PMS2 have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

Synthesized peptide derived from the C-terminal region of human PMS2/PMS2CL at AA range: 100-180

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

PMS2/PMS2CL Polyclonal Antibody detects endogenous levels of PMS2/PMS2CL protein.