Nectin 4 Polyclonal Antibody

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NECTIN4 (nectin cell adhesion molecule 4) encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in NECTIN4 are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Synthesized peptide derived from the Internal region of human Nectin 4 at AA range: 290-370

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Nectin 4 Polyclonal Antibody detects endogenous levels of Nectin 4 protein.