PI 3-kinase p101 Polyclonal Antibody

Gel pack with blue ice.

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: i, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.

Synthesized peptide derived from the C-terminal region of human PI 3-kinase p101 at AA rangle: 670-750

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

PI 3-kinase p101 Polyclonal Antibody detects endogenous levels of PI 3-kinase p101 protein.