Tie-2 (phospho Tyr1102) Polyclonal Antibody

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TEK (TEK receptor tyrosine kinase) encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in TEK are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of TEK have been described, but their full-length nature is not known.

Synthesized peptide derived from human Tie-2 around the phosphorylation site of Y1102

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Phospho-Tie-2 (Y1102) Polyclonal Antibody detects endogenous levels of Tie-2 protein only when phosphorylated at Y1102.