Caveolin-1 Polyclonal Antibody

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The scaffolding protein (caveolin 1) encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Synthesized peptide derived from the C-terminal region of human Caveolin-1 at AA range: 100-180

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Caveolin-1 Polyclonal Antibody detects endogenous levels of Caveolin-1 protein.