Na+ CP-pan Polyclonal Antibody

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Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. SCN1A encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of SCN1A are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.

Synthesized peptide derived from the Internal region of human Na+ CP-pan at AA range: 1440-1520

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Na+ CP-pan Polyclonal Antibody detects endogenous levels of Na+ CP-pan protein.