PP2A-Abeta Polyclonal Antibody

Gel pack with blue ice.

PPP2R1B encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. PPP2R1B encodes a beta isoform of the constant regulatory subunit A. Mutations in PPP2R1B have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.

Synthesized peptide derived from the C-terminal region of human PP2A-Abeta at AA range: 530-610

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

PP2A-Abeta Polyclonal Antibody detects endogenous levels of PP2A-Abeta protein.