TCF-3 Polyclonal Antibody

Gel pack with blue ice.

TCF3 encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1; 19), with PBX1), childhood leukemia (t(19; 19), with TFPT) and acute leukemia (t(12; 19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.

Synthesized peptide derived from the C-terminal region of human TCF-3 at AA range: 540-620

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

TCF-3 Polyclonal Antibody detects endogenous levels of TCF-3 protein.