Survivin Polyclonal Antibody

Gel pack with blue ice.

BIRC5 (baculoviral IAP repeat containing 5) is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for BIRC5.

Recombinant Protein

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

The antibody detects endogenous Survivin protein.