TLR2 Polyclonal Antibody

Gel pack with blue ice.

The protein encoded by TLR2 (toll like receptor 2) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. TLR2 is also thought to promote apoptosis in response to bacterial lipoproteins. TLR2 has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.

Recombinant Protein

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

The antibody detects endogenous TLR2 protein.