CAC1A Polyclonal Antibody

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Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. CACNA1A encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in CACNA1A are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. CACNA1A also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6.

Synthesized peptide derived from part region of human CAC1A protein at amino acid sequence of 1401-1450

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

The antibody detects endogenous levels of CAC1A protein