RGS4 Polyclonal Antibody

Gel pack with blue ice.

RGS4 (Regulator Of G Protein Signaling 4) is a Protein Coding gene. Diseases associated with RGS4 include Schizophrenia 9 and Schizophrenia. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 12. Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for RGS4.

Synthesized peptide derived from part region of human RGS4 protein at amino acid sequence of 80-160

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

The antibody detects endogenous levels of RGS4 protein