Antibodies

SCN1A Polyclonal Antibody

Hersteller Abbkine Scientific
Kategorie
Typ Antibody Polyclonal
Specific against Human, Rat
Isotype IgG
Applikationen WB, ELISA
Menge 200ul
Host Rabbit
ArtNr ABK-ABP60341-200ul
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Immunogen
Synthesized peptide derived from part region of human SCN1A protein
Applications notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
Formulation
Liquid solution
Concentration
1 mg/ml
Storage buffer
PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage instructions
Stable for one year at -20C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping
Gel pack with blue ice.
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Background
Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. SCN1A gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.
Gene ID
6323
Alternative
Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1
Other info
The antibody detects endogenous levels of SCN1A protein
Accession
P35498

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Menge: 200ul
Lieferbar: In stock
Listenpreis: 519,44 €
Preis: 519,44 €
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