HIF-1 beta/ARNT Monoclonal Antibody

Gel pack with blue ice.

ARNT (aryl hydrocarbon receptor nuclear translocator) encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of ARNT with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.

Recombinant Protein

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.