MKP1

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, IF
Protein Familie MAPK Signaling
Menge 100ug
Host Rabbit
ArtNr A0876
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
39kDa
Immunogen
A synthetic peptide of human DUSP1
Gene ID
1843
Swiss Prot
P28562
Synonyms
HVH1; MKP1; CL100; MKP-1; PTPN10;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Recommended Dilutions
WB 1:500-1:1000 IF 1:20-1:50
illustration
Western blot analysis of extracts of 293 celllines, using DUSP1antibody.

Arbeitsanleitung

A0876.pdf

Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
lieferbar

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