MKP1

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human
Applications	WB, IF
Protein Family	MAPK Signaling
Amount	100ug
Host	Rabbit
Item no.	A0876
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	39kDa
Immunogen	A synthetic peptide of human DUSP1
Gene ID	1843
Swiss Prot	P28562
Synonyms	HVH1; MKP1; CL100; MKP-1; PTPN10;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Recommended Dilutions	WB 1:500-1:1000 IF 1:20-1:50
illustration	Western blot analysis of extracts of 293 celllines, using DUSP1antibody.

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