STAT4 Rabbit mAb

Monoclonal Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

A synthetic peptide corresponding to a sequence within amino acids 649-748 of human STAT4 (NP_003142.1).

86kDa

Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Signal Transduction, ErbB-HER Signaling Pathway, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway.

6775

STAT4