Phospho-BCR-Y177 Rabbit pAb

Phosphorylated Antibodies

Store at -20°C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.

A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3).

143kDa

Protein phosphorylation, Cancer, Signal Transduction, G protein signaling, Small G proteins, Kinase, Serine threonine kinases, PI3K-Akt Signaling Pathway, Immunology Inflammation, B Cell Receptor Signaling Pathway, NF-kB Signaling Pathway.

613

BCR