Bcl10

Hersteller	Abclonal
Typ	Antibody Polyclonal
Specific against	Human, Mouse
Applikationen	WB, IHC
Protein Familie	Lymphocyte Signaling
Menge	100ug
Host	Rabbit
ArtNr	A0191
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
*	DESCRIPTION
Calculated MW	26kDa
Immunogen	Recombinant protein of human BCL10
Gene ID	8915
Swiss Prot	O95999
Synonyms	CLAP; mE10; CIPER; c-E10; CARMEN;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Recommended Dilutions	WB 1:500-1:2000 IHC 1:50-1:200
illustration	Western blot analysis of extracts of Mouse ovary, using BCL10 antibody.

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