Bcl10

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human, Mouse
Applications	WB, IHC
Protein Family	Lymphocyte Signaling
Amount	100ug
Host	Rabbit
Item no.	A0191
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	26kDa
Immunogen	Recombinant protein of human BCL10
Gene ID	8915
Swiss Prot	O95999
Synonyms	CLAP; mE10; CIPER; c-E10; CARMEN;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Recommended Dilutions	WB 1:500-1:2000 IHC 1:50-1:200
illustration	Western blot analysis of extracts of Mouse ovary, using BCL10 antibody.

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